Latenna the Albinauric: 

Talk to Elden Ring Items Her After Acquiring the Haligtree Secret Medallion

How to Save: 

Latenna is an Albinauric NPC found in Liurnia of the Lakes at the Lakeside Crystal Cave. She requests to be taken to the Consecrated Snowfields, but she can only be saved if you possess the Haligtree Secret Medallion, which can be acquired from Albus in the Village of the Albinaurics.

Once you obtain the medallion, talk to Latenna, and she will request that you accompany her to the Consecrated Snowfields. This will trigger her quest, allowing you to recruit her as a spirit summon and help her fulfill her fate.

4. Millicent: 

Give Her the Unalloyed Gold Needle

How to Save: 

Millicent's questline is one of the most intricate in Elden Ring. She is first encountered in Caelid at the Church of the Plague, where she is suffering from a Scarlet Rot infection. To save her temporarily, players must first defeat Commander O'Neil in the Swamp of Aeonia, who drops the Unalloyed Gold Needle.

Once you have the Elden Ring Items(needle), take it to Gowry to repair it. Afterward, give it to Millicent to halt her Scarlet Rot infection, saving her for a time. Unfortunately, she still succumbs to her fate later in her questline, but her sacrifice is one she makes with her own will, offering players a bittersweet conclusion.

5. Boc the Seamster: 

Saved Throughout His Questline

How to Save: 

Boc is an NPC that many players encounter early on in Limgrave, where he has been turned into a bush. After freeing him, players can help Boc with his quest to become human again, which involves using a Larval Tear to allow him to undergo rebirth at Rennala's rebirthing statue.

However, this transformation comes with a catch. If you allow him to become human, Boc will soon die. To save him, instead of rebirthing him, use the “You're Beautiful” Prattling Pate gesture. If you answer "yes" when he asks if he's beautiful, Boc will be spared and will live to Elden Ring Runes buy continue his role as a helpful NPC.