Enemy Resistances and Path of Exile 2 Currency Penetration:
Enemy resistances reduce damage according to their resist values, while penetration mechanics reduce these resistances temporarily to increase damage dealt.

Damage Taken Modifiers:
Additional modifiers on the enemy, such as increased damage taken from hits or spells, are factored in here.

Damage Avoidance:
After damage calculation, avoidance mechanics like dodge, block, or evasion chance determine if damage is mitigated or negated.

Defense Calculation Highlights
Evasion and Dodge:
Determine if an enemy avoids incoming hits entirely.

Block:
Chance to reduce or negate damage.

Armour and Energy Shield:
Reduce or absorb incoming damage before it affects life.

Life Regeneration and Recovery:
Heal damage over time.

Why This Matters
Build Optimization: Knowing when each modifier applies allows you to prioritize stats and gear that maximize damage or survivability.

Strategic Planning: Some effects interact differently depending on POE 2 Orbs for sale their place in the order, impacting how you approach combat.