The impact of acromegaly extends far beyond physical symptoms, often leading to significant psychosocial distress. The slow, progressive change in facial features and body habitus can cause body image distortion, social withdrawal, and clinical depression. Even after biochemical "cure" is achieved, many of the skeletal changes are irreversible, and patients may continue to suffer from chronic joint pain (arthropathy) and fatigue.

Clinical studies using validated tools like the AcroQoL (Acromegaly Quality of Life) questionnaire have shown that patients often score lower than the general population in areas of physical function and emotional well-being. Trends in patient-centric care models and the rise of specialized support groups are documented in the Acromegaly Market patient advocacy reports. Managing acromegaly effectively requires a holistic approach that includes psychological counseling and pain management alongside traditional hormonal therapy to ensure a true restoration of the patient's wellbeing.